Description of Research:
1.Gene polymorphisms have been shown to play an important role in childhood acute lymphoblastic leukemia (ALL). These variations interact with different environmental factors, thus increases the individual’s susceptibility to ALL. The team investigates the mechanism that trigger leukemic development through their interaction with the various environmental risk factors. In particular, the group aims to understand the drug-metabolizing pathway that are critical for the dialogue between leukemia cells and the micro environmental cells and could serve as target for novel treatments. Moreover the group is benefitting from a strong clinical trials portfolio of the Kashmiri ALL study group.
2.To understand the role of gene mutation in DNA repair pathway in Breast cancer patients. We are interested in evaluation of role of promoter methylation of different genes of GST family of enzymes and Base excision Repair Pathway with relation to its polymorphism, expression and clinicopathological parameters in Breast cancer patients.
3.The group also trying to understand the role of MicroRNAs in different disease manifestation, including type 2 Diabetes mellitus (T2DM). Specific miRNA such as miR-155 has been initially linked with the inflammatory pathways. The major objective of our research group is to evaluate the expression of miR-155 in T2DM and its associated microvascular complications that may be useful in targeted therapy with clinical implications.