Description of Research:

 

Our lab is interested in understanding the genetic epidemiology of PCOS and how genetic variants and long-coding RNAs are involved in its pathogenesis and heterogeneous phenotypic manifestations.  We employ animal models of PCOS to check changes in expression patterns and how natural products can be used to ameliorate PCOS.

 

Currently, our main focus is on the role of insulin resistance and oxidative stress in the pathogenesis of PCOS. We are also working on the identification of some novel biomarkers for PCOS-associated infertility.

Research Projects:

Completed:

 

  • Title:              Insulin gene VNTR polymorphism in Kashmiri women with   polycystic  ovary syndrome

Funding Agency:     ICMR, New Delhi

  • Title:                 Expression analysis and polymorphism of CYP11, CYP17 and CYP19 gene and their relationship with hyperandrogenism and PCOS in Kashmiri women 

      Funding Agency:  Department of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi

  • Title:                      Expression analysis of long non coding RNAs (LncRNAs)      and  their  association with polycystic ovary syndrome (PCOS): A case control study

Funding Agency:     ICMR, New Delhi

Ongoing: 

 

Title:              Elucidating the role of Angiopoietin-1/Angiopoitin-2 in    infertility in polycystic ovarian syndrome women

Funding Agency:     JK Science Technology and Innovation Council, Srinagar

Lab Members

Past Members

    1. Sadaf Gulzar   (M.Phil)
    2. Syed Rakhshanda   (M.Phil &Ph.D.)
    3. Farukh Rana    ((M.Phil &Ph. D.)
    4. Mohd Ishaq Dar    (M. Phil)
    5. Shayaq ul Abeer (Ph.D.)
    6. Sairish Ashraf ((M.Phil &Ph.D.)
    7. Mudasar Nabi  ((M.Phil &Ph.D.)
    8. Syed Sakina  (M.Phil.)

     

     

    Current Members

    1. Sana Hafiz (CSIR-JRF)
    2. Safeena  Rashid (CSIR-UGC-NET-JRF)
    3. Wasim Younis Khan((CSIR- UGC-JRF)-JRF)
    4. Zainab Mushtaq  ( NET)
    5. Munaza  Rafiq  (NET)
    6. Falak un Nisa  (SET)
    7. Iqra Nisar   (Master’s internee)

Recent Publications:

S.No                                              Publication
72.

Mudasar Nabi,  Shayaq Ul Abeer Rasool, Sairish Ashraf, Syed Mudasir Majid  and Shajrul Amin (2023). Androgen receptor signalling transactivator lncRNAs PRNCR1 and PCGEM contribute to PCOS pathogenesis (Under review). Scientific Reports. 
71.

Shayaq Ul Abeer Rasool, Mudasar Nabi, Sairish Ashraf and Shajrul Amin (2022). Insulin receptor substrate1 Gly972Arg (rs1801278) polymorphism is associated with obesity and insulin resistance in Kashmiri women with polycystic ovary syndrome Genes 13(8), 1463
70

Mudasar Nabi, Syed Mudasir Andrabi, Shayaq Ul Abeer Rasool, Sairish Ashraf, Imran Majid and Shajrul Amin(2022). Androgen receptor coregulator long Non coding RNA CTBP1-AS is associated with polycystic ovary syndrome in Kashmiri women. Endocrine 75: 614-622
69

Shayaq Ul Abeer Rasool, Sairish Ashraf, Mudasar Nabi,  Shariq R. Masoodi, Khalid M. Fazili, Shajrul Amin (2021). Clinical Manifestations of hyperandrogenism and ovulatory dysfunction are not associated with His1058 C/T SNP (rs1799817) polymorphism of insulin receptor gene tyrosine kinase domain in Kashmiri women with PCOS.International Journal of Endocrinology 2021:1-10
68

Sairish Ashraf, Shayaq ul Abeer Rasool, Mudasar Nabi,   Mohd Ashraf Ganie, Shajrul Amin (2021). Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women. Scientific Reports 11: 12942 
67

Sairish Ashraf, Shayaq ul Abeer Rasool, Mudasar Nabi,   Mohd Ashraf Ganie, Shajrul Amin (2021). CYP17 gene polymorphic sequence variation is associated with hyperandrogenism in Kashmiri women with polycystic ovarian syndrome. Gynecological Endocrinology 37 (3): 230-234.
66

Khalid Bashir Dar, Ishfaq Shafi Khan, Shajrul Amin, Aijaz Ganie Aashiq Hussain Bhat, Showkat A. Dar, Bilal Ahmad Reshi Showkat Ahmad Ganie (2020). Active Cousinia thomsonii extracts modulate expression of crucial proinflammatory mediators/ cytokines and NFκB cascade in lipopolysaccharide-induced albino wistar rat model. Journal of Inflammation Research 13: 829-845
65